With the exception of story achievements, all other achievements in this game can be missed. Although some are quite hard to miss, it is still possible to do so. If your goal is to achieve 100% completion, don't worry about achievements during your first playthrough, as multiple runs will be necessary to attain them all.

Resident Evil 4 Remake

Story Achievements

The following story-related achievements cannot be missed.

Harpoon Hurler

Grilled Big Cheese

Wave Goodbye, Right Hand

No Thanks, Bro!

You Used to Be a Good Guy

You’re Small Time!

Combat / Upgrade Achievements

Knife Basics

Parry an enemy with the knife

Use the knife to deflect an enemy attack.

My Preferred Place

Upgrade a weapon

At the Merchant, use Ptas to upgrade a weapon.

A Masterpiece

Get the exclusive upgrade for a weapon

After fully upgrading a weapon, a new, expensive upgrade will become available for purchase.

Gun Fanatic

Obtain all weapons

The majority of weapons can be bought from the Merchant, while certain weapons will become available during NG+ playthroughs as a reward for accomplishing specific feats. You can find a comprehensive list of all weapons in the order they appear in the game in the "All Collectables in Order of Appearance" section of this guide.

Shield Your Eyes

Defeat 3 enemies at once with a Flash Grenade

In order to do this you must shoot the heads of 3 enemies causing the parasite to emerge from their necks. While this can sometimes be unpredictable, it's possible to force it by fighting the armored enemies, as they always have a parasite.

Never Heard It Coming

Defeat a Garrador using only Knives

A Garrador is the blind armored enemy. You have to kill it completely using only knives. Sprint to alert it and it will charge you. He should then get stuck in a wall allowing for some free hits.

Two Bugs, One Stone

Kill 3 parasites inside a Regenerator with a single bullet

Not quite sure what weapon will be best for this achievement at the moment. Will update when more information becomes available.

You Talk Too Much!

Throw a grenade into Ramón Salazar’s mouth

During this boss fight, throw a grenade into Ramón Salazar’s mouth.

Overkill

Use a cannon to defeat a zealot

Hope You Like Thrill Rides!

Make it through both minecart sections in the underground tunnel without taking damage

This might just take a few attempts. If you take damage, just load a previous checkpoint.

Capacity Compliance

Reach the top of the clock tower without the lift stopping once

To obtain this, you need to defeat enemies rapidly as they jump onto the lift. If too many enemies accumulate on the lift, it will come to a halt.

Smooth Escape

Escape on the water scooter without taking any damage

At the end of the game, complete the water scooter section without taking damage.

Talk About Near-Death Experience!

Rescue Ashley as she’s being carried away by the enemy

If an enemy gets too close to Ashley, they will try to grab her and take her away. To prevent this, shoot the enemy in the leg, which will cause them to release her.

Clockwork Castellan Achievements

To find all clockwork castellan and other collectibles, check out our guide to find all collectibles in Resident Evil 4 Remake.

A Clockwork Castellan

Revolt Against the Revolting

Destroy a Clockwork Castellan

Revolution Wind-Up

Destroy all Clockwork Castellans

Run Specific Achievements

Players need to beat the game at least 2 times.

These achievements stack - you can complete the game in Professional and it would unlock all the achievements for previous difficulties.

Promising Agent

Complete the main story on Standard mode or higher

Mission Accomplished S+!

Complete the main story on Standard mode with an S+ rank

Proficient Agent

Complete the main story on Hardcore mode or higher

S+ Rank Investigator

Complete the main story on Hardcore mode with an S+ rank

Peerless Agent

Complete the main story on Professional mode with an S+ rank

Sprinter

Complete the main story within 8 hours

Easier on NG+ and on lower difficulties.

Frugalist

Complete the main story without using a recovery item

Minimalist

Complete the main story using only Knives and Handguns [Including specific battles]

Silent Stranger

Complete the main story without talking to the Merchant once

It seems possible to earn the Frugalist, Minimalist, and Silent Strange achievements by playing through NG+ with a fully upgraded pistol. In this case, there would be no need to interact with the Merchant and it would be possible to reload a checkpoint if you sustain damage. However, it's worth noting that certain bosses may prove challenging, so it may be necessary to attempt the Frugalist achievement separately.

Misc Achievements

There are a lot of missables.

Nice One, Stranger!

Complete a request for the Merchant

The Merchant has requests you can complete throughout the game for rewards. Complete 1 of them for this achievement.

Jack of All Trades

Complete all requests from the Merchant

The Merchant has 19 requests you can complete throughout the game for rewards. Complete all of them for this achievement. All are listed above in the "All Collectables in Order of Appearance" section of this guide.

Astute Appraiser

Sell a single Treasure for at least 100000 Ptas

As you progress, you'll get more and more valuable items you can sell to the Merchant.

Bandit

Obtain all Treasures indicated on the Village Treasure Map in a single playthrough

You can purchase the treasure maps from the merchant and all valuable items will be marked on your map.

Raider

Obtain all Treasures indicated on the Castle Treasure Map in a single playthrough

You can purchase the treasure maps from the merchant and all valuable items will be marked on your map.

Burglar

Obtain all Treasures indicated on the Island Treasure Map in a single playthrough

You can purchase the treasure maps from the merchant

and all valuable items will be marked on your map.

Amateur Shooter

Complete a game at the shooting range

You'll be able to play this minigame after making it to the Castle. Simply complete 1 round with any amount of points.

Trick Shot

Shoot through and destroy 5 targets at the shooting range with a single shot

Real Deadeye

Earn an S-rank in all games at the shooting range

Get an S-rank in each game at the shooting range.

>>> Read more: 5 Tips And Tricks To Beat Resident Evil 4 Remake Easily