Leon is on a mission to rescue Ashley, who has been kidnapped, in the Resident Evil 4 remake. He will encounter various bosses of differing levels of difficulty, which will pose challenges for him as he progresses through the game. Despite the fact that the protagonist and Ashley always come out on top in the story, players must survive these boss battles to advance. Each boss has its own unique set of moves, with some being easier to defeat than others.

Although the bosses in the RE4 remake have received major visual updates, the boss fights themselves have remained largely unchanged from the original game. Players who played the previous game may recognize similar attack patterns as they progress through the remake and attempt to achieve a high rank.

In this article, Gurugamer is going to showcase a list of all boss fights in Resident Evil 4 Remake, ranked by difficulty.

1. Mutated Krauser

The most challenging boss battle in the Resident Evil 4 remake is against Krauser's transformed state. As revenge for his prior loss, Krauser unleashes his powerful mutated form during his final encounter with Leon. Krauser's combination of a large claw-like arm and military training makes him a formidable opponent. Players must match Krauser's incredible speed to avoid his unpredictable and deadly attacks, including head crushing grabs.

Re4 Remake Death Animations Krauser

Additionally, players must deal significant damage to stagger him momentarily. Krauser can only be defeated through careful trigger control, consistent dodging, and endless patience, with most players requiring several attempts to beat this toughest boss in the Resident Evil 4 remake.

2. Verdugo

In the Resident Evil 4 remake, defeating Verdugo is a challenging task that will likely leave players feeling bewildered during their initial attempts to take down Salazar's personal bodyguard. With its quick and formidable attacks, this tailed creature requires a full-out effort from players to defeat it.

Re4 Remake Verdugo Boss Fight

The only way to kill Verdugo is to temporarily freeze it, followed by firing as many bullets and grenades as possible. This requires precise timing, as Verdugo is always on the prowl and ready to strike, and players will need to have powerful weapons at their disposal to succeed.

3. Twin Garradors

The Twin Garradors may not be officially considered bosses in the RE4 remake, but they should still be treated as such, since they pose a major challenge to players. Unlike other enemies, these creatures have excellent hearing and can detect Leon with ease, charging at him relentlessly. Since the area is teeming with Los Iluminados, this makes things even more difficult.

Twin Garradors Re4 Remake Boss Fight

To defeat them, players must either lure them into attacking other enemies or use the scattered bells in the area, but this is a slow and risky process that can quickly go wrong if players are caught.

4. Ramón Salazar

The encounter with Ramón Salazar in the Salazar Castle presents a challenging battle for players. This boss fight can be quite frustrating because of Salazar's large size, his explosive sacs that take up a lot of space, and his attacks that spit poison at Leon periodically. Adding to the difficulty, Salazar can instantly kill Leon if he gets too close, swallowing him whole like popcorn.

Salazar Fight Re4 Remake Boss

To defeat Salazar, players must stay on the move while relentlessly attacking, making this boss fight one of the more difficult ones in the Resident Evil 4 remake.

5. Osmund Saddler

While Osmund Saddler is the mastermind behind the Ganados and Los Iluminados, he isn't as difficult as he seems. His ultimate form is disgusting, and his voice lines are creepy, but with some perseverance, rapid reflexes, and a continuous barrage of gunfire aimed at his eyes, the cult leader can be defeated. If players have been conserving ammo and upgrading their weapons properly, they will find it relatively easy to disintegrate Saddler into bits by the end of the boss fight in the Resident Evil 4 remake.

Resident Evil 4 Remake Final Boss Saddler

6. Jack Krauser (Human)

In the Resident Evil 4 remake, previously underdeveloped characters such as Leon's former military comrade, Jack Krauser, have received more backstory. However, despite this, Krauser is still hostile towards Leon during their first meeting. The two engage in a knife fight that requires the player to parry accurately and consistently. If their combat knife is worn out, the fight becomes even more challenging, making it one of the toughest boss battles in the RE4 remake.

Resident Evil 4 Remake Krauser

7. Del Lago

Like with Méndez, navigating through obstacles is crucial when facing Del Lago in the Resident Evil 4 remake. The challenge in this boss fight comes from the need to avoid rocks and other hazards that are scattered throughout the lake, which can be especially tricky given the sometimes clumsy controls of Leon's boat. Additionally, players won't have the option to heal during the fight, so they'll have to make every shot with their harpoon count, and make skillful maneuvers to avoid taking damage.

Del Lago Re4 Remake Boss Fight

8. Father Méndez

The RE4 remake enhanced the horror factor of the most frightening monster, making Father Méndez seem just as scary upon first sight. But players will soon discover that he's actually one of the easiest bosses to defeat. As long as they can stay in a position of advantage and dodge his attacks during the boss fight, the bulky village chief won't be too menacing. If players shoot the explosive barrels before Méndez has the chance to hurl them, he can be defeated rather swiftly.

Mendez Boss Fight Re4 Remake

9. Twin Gigantes

The Twin Gigantes boss fight in the RE4 remake can be easily defeated with the help of Leon's ally, Luis. This is because both Gigantes can be distracted by Luis and attacked by Leon one at a time. The Armored El Gigante can also be weakened with dynamite, which allows Leon to deliver the final blow. Additionally, there's a safety measure of dropping the Armored El Gigante into the lava below the floor by using a hatch.

Twin Gigante Re4 Remake Boss Fight

10. El Gigante

El Gigante (Unarmored)

Ironically, defeating El Gigante in the RE4 remake is more challenging than taking down his armored variant. This is because Leon doesn't have access to a powerful cannon and must rely on his regular weapons, which are relatively weaker. However, if players rescue the trapped dog before this fight, the faithful companion will assist in distracting the towering beast. There are no specific techniques or strategies required to defeat El Gigante, except for the need to unload a considerable amount of bullets due to his enormous health pool.

Resident Evil 4 Remake El Gigante 2 By Venom Rules

El Gigante (Armored)

Despite its appearance, the Armored El Gigante is the simplest boss to defeat in the Resident Evil 4 remake. The large creature may throw rocks at Leon and make a lot of noise, but players have access to a functional cannon that can defeat it easily. Players need only to have accurate aim and avoid incoming debris, making the fight more about timing and precision. The only remaining fear is the surprise return of the El Gigante in the next area, unarmored.

Armored Gigante Re4 Remake Boss

The Resident Evil game franchise has been popular since its debut in 1996. The remake has even been ranked as most downloaded game in March 2023. In addition to its success as a game franchise, Resident Evil has also been adapted into films and books. The popularity of the franchise has also extended to online slots, with especially many Dutch casino players enjoying the Resident Evil-themed games. OnlineCasinoGround.nl is a one of the Dutch casino platforms where players can find and play these online slots.

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